Face validity of the Kids' ITP Tools (KIT) in the era of thrombopoietin receptor agonists

Pediatr Blood Cancer. 2024 Apr;71(4):e30888. doi: 10.1002/pbc.30888. Epub 2024 Jan 24.

Abstract

The Kids' ITP Tools (KIT) is a questionnaire to assess quality of life of children with immune thrombocytopenia (ITP). The aim of this study was to update this previously validated tool to align with changes in clinical practice, specifically, treatment with thrombopoietin receptor agonists (TPO-RAs). Children aged 1-18 with ITP and/or their families were recruited to participate in interviews to review the KIT. Twenty-six interviews were conducted. Based on interview data from children and families, current guidelines, and expert opinion, five changes were made to the KIT in order to improve its face validity.

Keywords: immune thrombocytopenia; quality of life; thrombopoietin receptor agonists (TPO-RA).

MeSH terms

  • Benzoates / therapeutic use
  • Child
  • Humans
  • Hydrazines / therapeutic use
  • Purpura, Thrombocytopenic, Idiopathic* / drug therapy
  • Quality of Life
  • Receptors, Fc / therapeutic use
  • Receptors, Thrombopoietin / agonists
  • Recombinant Fusion Proteins / therapeutic use
  • Reproducibility of Results
  • Thrombopoietin / therapeutic use

Substances

  • Receptors, Thrombopoietin
  • Thrombopoietin
  • Hydrazines
  • Recombinant Fusion Proteins
  • Receptors, Fc
  • Benzoates