Severe hypercalcemia as a result of disseminated Candida krusei infection

Amenah Alghamdi; Torrance Oravec; Cesilia Nishi; Eric Eckbo; Krista Marcon; Alissa Wright; Allison Mah; Jennifer White; Tom Nevill; Sara Belga

doi:10.1016/j.ijid.2024.01.012

Severe hypercalcemia as a result of disseminated Candida krusei infection

Int J Infect Dis. 2024 Mar:140:110-112. doi: 10.1016/j.ijid.2024.01.012. Epub 2024 Jan 22.

Authors

Affiliations

¹ Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada; Department of Medicine, Division of Infectious Diseases, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: [email protected].
² Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada.
³ Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada; Department of Pharmaceutical Sciences, Vancouver General Hospital, Vancouver, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
⁴ Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Laboratory Medicine, Vancouver Coastal Health, Vancouver, Canada.
⁵ Leukemia Bone Marrow Transplant Program of BC, British Columbia Cancer Agency, Vancouver, Canada; Department of Medicine, Division of Hematology, University of British Columbia, Vancouver, Canada.
⁶ Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada; Vancouver Coastal Health Research Institute, Vancouver, Canada.

PMID: 38266977
DOI: 10.1016/j.ijid.2024.01.012

Abstract

Candida krusei disseminated infection is a rare complication of protracted neutropenia. Herein, we report a case of a 31-year-old male with relapsed acute myeloid leukemia who developed Candida krusei fungemia with cutaneous, ocular, splenic, renal, bone marrow and osseous involvement leading to severe hypercalcemia, treated with parenteral antifungals followed by oral ibrexafungerp.

Keywords: Candida krusei; Hypercalcemia; Invasive candidiasis; Pichia kudriavzevii.

Publication types

Case Reports

MeSH terms

Adult
Antifungal Agents / therapeutic use
Candidiasis* / complications
Candidiasis* / diagnosis
Candidiasis* / drug therapy
Fungemia*
Humans
Hypercalcemia* / complications
Hypercalcemia* / drug therapy
Male
Pichia*

Substances

Antifungal Agents

Supplementary concepts

Pichia kudriavzevii
Systemic candidiasis