Health-related quality of life in men with oligometastatic prostate cancer following metastases-directed stereotactic body radiotherapy: Real-world data from the E2-RADIatE OligoCare cohort

Renée Bultijnck; Mieke Van Hemelrijck; Valérie Fonteyne; Lorenzo Livi; Barbara Alicja Jereczek-Fossa; Hossein Hemmatazad; Michael Mayinger; Heike Peulen; Luc Verbeke; Sara Ramella; Pablo Castro; Pelagia Tsoutsou; Karin Stellamans; Adnan Shaukat; Miha Orazem; Paul Jeene; Pètra Braam; Helena Verkooijen; Inga-Malin Simek; Filippo Alongi; Enrico Clementel; Catherine Fortpied; Abigirl Machingura; Felix Boakye Oppong; Matthias Guckenberger; Piet Ost

doi:10.1016/j.ctro.2023.100715

Health-related quality of life in men with oligometastatic prostate cancer following metastases-directed stereotactic body radiotherapy: Real-world data from the E²-RADIatE OligoCare cohort

Clin Transl Radiat Oncol. 2023 Dec 29:45:100715. doi: 10.1016/j.ctro.2023.100715. eCollection 2024 Mar.

Authors

Renée Bultijnck^{1

2}, Mieke Van Hemelrijck³, Valérie Fonteyne^{1

2}, Lorenzo Livi^{4

5}, Barbara Alicja Jereczek-Fossa^{6

7}, Hossein Hemmatazad⁸, Michael Mayinger⁹, Heike Peulen¹⁰, Luc Verbeke¹¹, Sara Ramella^{12

13}, Pablo Castro¹⁴, Pelagia Tsoutsou¹⁵, Karin Stellamans¹⁶, Adnan Shaukat¹⁷, Miha Orazem¹⁸, Paul Jeene¹⁹, Pètra Braam²⁰, Helena Verkooijen²¹, Inga-Malin Simek²², Filippo Alongi²³, Enrico Clementel²⁴, Catherine Fortpied²⁴, Abigirl Machingura²⁴, Felix Boakye Oppong²⁴, Matthias Guckenberger⁹, Piet Ost^{1

25}

Affiliations

¹ Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
² Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
³ School of Cancer and Pharmaceutical Studies, Translational Oncology and Urology Research (TOUR), King's College London, London, UK.
⁴ Department of Experimental and Clinical Biomedical Sciences M Serio, University of Florence, Florence, Italy.
⁵ Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
⁶ Dept. of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
⁷ Dept. of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.
⁸ Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Switzerland.
⁹ Department of Radiation Oncology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
¹⁰ Catharina Ziekenhuis, Radiation Oncology, Eindhoven, the Netherlands.
¹¹ Onze-Lieve-Vrouw Ziekenhuis, Radiation Oncology, Aalst, Belgium.
¹² Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy.
¹³ Research Unit of Radiation Oncology, Department of Medicine and Surgery, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.
¹⁴ Health Research Institute Hospital Universitario de La Princesa.
¹⁵ Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie, Genève, Switzerland.
¹⁶ Campus Kennedylaan, AZ Groeninge Kortrijk, Kortrijk, Belgium.
¹⁷ NHS Grampian - Aberdeen Royal Infirmary, Aberdeen, Scotland.
¹⁸ Institute of Oncology, Division of Radiation Oncology, Ljubljana, Slovenia and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
¹⁹ Radiotherapiegroep, Deventer, the Netherlands.
²⁰ Radboud University Medical Center Nijmegen, Radiation Oncology, Nijmegen, the Netherlands.
²¹ University Medical Center Utrecht, Utrecht, the Netherlands.
²² Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
²³ IRCCS Sacro Cuore Don Calabria Hospital & University of Brescia, Radiation Oncology, Verona, Italy.
²⁴ European Organisation for Research and Treatment of Cancer (EORTC), Headquarters, Brussels, Belgium.
²⁵ Iridium Network, Radiation Oncology, Wilrijk, Belgium.

Abstract

Objective: To evaluate the impact of metastases-directed stereotactic body radiotherapy (SBRT) on health-related quality of life (HRQoL) in men with oligometastatic prostate cancer (PCa) using real-world data from the OligoCare cohort.

Materials and methods: OligoCare is a pragmatic, observational cohort designed to assess the impact of metastases-directed SBRT on patients with oligometastatic disease (OMD). We report an interim analyses of the secondary endpoint HRQoL, assessed using the EORTC QLQ-C30, within six months of metastases-directed SBRT for oligometastatic disease in men with PCa among the first 1600 registered patients. HRQoL data collection was optional within the OligoCare cohort. To compare HRQoL between baseline and first follow-up assessment, a Wilcoxon signed-rank test was used. A multiple linear regression model was used to explore the HRQoL associations with predefined factors.

Results: Out of the 1600 registered patients, 658 were treated for oligometastatic PCa, of which 233 had baseline QoL data and 132 patients had both baseline and follow-up HRQoL data. At baseline, most patients had a WHO performance status of 0 or 1 (87 %), were de-novo oligometastatic (79 %), had one metastasis (90 %), and had a good overall global health status (mean 80.81, SD16.11, IQR 75-92). 51 % received hormonal therapy as concomitant systemic treatment. Patients with comorbidities as assessed by the Charlson Comorbidity index had a worse global health status at baseline (-4.88, 95 % CI:-9.35, -0.42). No clinically meaningful significant difference in global health status was observed at first assessment following SBRT (median 3.0 months) compared with baseline (mean difference 2.27, 95 % CI:-1.54, 6.08). Upon evaluating the proportions, meaningful clinically important differences (a 10-point or more difference) was observed in, 17 % and 11 % of the patients reporting deterioration and improvement of global health status, respectively.

Conclusion: Metastases-directed stereotactic body radiotherapy had no negative impact on global HRQoL within the first six months after treatment.