Integration of the Molecular Classification of Endometrial Carcinoma to Select Patients for Fertility Sparing Strategies

Anticancer Res. 2024 Feb;44(2):445-452. doi: 10.21873/anticanres.16832.

Abstract

Fertility-sparing treatment (FST) for endometrial carcinoma (EC) is an option for a subgroup of young women with low-risk disease. The low-risk group comprises patients with endometrioid EC stage IA, grade 1, with or without focal lymphovascular invasion. In the era of molecular subtyping, treatment de-escalation for some EC subtypes is recommended. Recommendations for fertility-preserving treatments were developed regardless of the molecular classification of EC. However, few studies have focused on this topic. In this review, we summarize the actual data available in the literature and discuss the impact of some molecular subtypes of FST.

Keywords: Endometrial cancer; MMR; P53; POLE; fertility; molecular classification; review.

Publication types

  • Review

MeSH terms

  • Carcinoma, Endometrioid* / pathology
  • Endometrial Neoplasms* / genetics
  • Endometrial Neoplasms* / pathology
  • Endometrial Neoplasms* / therapy
  • Female
  • Fertility
  • Fertility Preservation*
  • Humans
  • Retrospective Studies
  • Risk Factors