Bi-allelic PRRT2 variants may predispose to Self-limited Familial Infantile Epilepsy

Eur J Hum Genet. 2024 Oct;32(10):1338-1342. doi: 10.1038/s41431-024-01541-x. Epub 2024 Feb 5.

Abstract

Heterozygous PRRT2 variants are frequently implicated in Self-limited Infantile Epilepsy, whereas homozygous variants are so far linked to severe presentations including developmental and epileptic encephalopathy, movement disorders, and intellectual disability. In a study aiming to explore the genetics of epilepsy in the Sudanese population, we investigated several families including a consanguineous family with three siblings diagnosed with self-limited infantile epilepsy. We evaluated both dominant and recessive inheritance using whole exome sequencing and genomic arrays. We identified a pathogenic homozygous splice-site variant in the first intron of PRRT2 [NC_000016.10(NM_145239.3):c.-65-1G > A] that segregated with the phenotype in this family. This work taps into the genetics of epilepsy in an underrepresented African population and suggests that the phenotypes of homozygous PRRT2 variants may include milder epilepsy presentations without movement disorders.

Publication types

  • Case Reports

MeSH terms

  • Alleles
  • Child
  • Child, Preschool
  • Epilepsy / genetics
  • Female
  • Homozygote
  • Humans
  • Infant
  • Male
  • Membrane Proteins* / genetics
  • Mutation
  • Nerve Tissue Proteins* / genetics
  • Pedigree*
  • Phenotype

Substances

  • PRRT2 protein, human
  • Nerve Tissue Proteins
  • Membrane Proteins