Association of Rs7217186 Polymorphism of Arachidonic Acid 15-Lipoxygenase (ALOX15) Gene with Susceptibility to Allergic Rhinitis

Atefeh Eivazi; Bahman Akbari; Sara Falahi; Ali Gorgin Karaji; Alireza Rezaiemanesh; Seyed Hamid Reza Mortazavi; Niloofar Daneshfar; Farhad Salari

doi:10.61186/rbmb.12.2.269

Association of Rs7217186 Polymorphism of Arachidonic Acid 15-Lipoxygenase (ALOX15) Gene with Susceptibility to Allergic Rhinitis

Rep Biochem Mol Biol. 2023 Jul;12(2):269-276. doi: 10.61186/rbmb.12.2.269.

Authors

Atefeh Eivazi¹, Bahman Akbari², Sara Falahi¹, Ali Gorgin Karaji³, Alireza Rezaiemanesh³, Seyed Hamid Reza Mortazavi⁴, Niloofar Daneshfar¹, Farhad Salari³

Affiliations

¹ Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
² Department of Biotechnology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
³ Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁴ Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

Background: Allergic rhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins.

Methods: In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX (ALOX15) gene, using SNPinfo and Regulome DB tools.

Results: The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (P> 0.05).

Conclusions: The present results indicated that rs7217186 polymorphism of ALOX15 gene might be a potential biomarker for susceptibility to AR.

Keywords: Allergic rhinitis; Arachidonate 15-lipoxygenase; Immunoresolvents; Single-nucleotide polymorphism; Specialized proresolving lipid mediators (SPMs).