Three new griseofulvin derivatives from Aureobasidium pullulans

Nat Prod Res. 2024 Feb 8:1-6. doi: 10.1080/14786419.2024.2312428. Online ahead of print.

Abstract

Three new griseofulvin derivatives, griseofulvinoside A-C (1-3), were isolated from the ethyl acetate extract of the solid fermentation product of Aureobasidium pullulans. Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR. The antifungal activities of new compounds were evaluated against four phytopathogenic fungi in vitro, and all test compounds demonstrated inhibitory effects. Among them, compound 2 exhibited the most potent activities against the four selected phytopathogenic fungi with inhibitory rates ranging from 40.2 to 75.8% at 0.2 mg/mL.

Keywords: Aureobasidium pullulans; antifungal activity; griseofulvins; phytopathogenic fungi.