Programmable RNA N6-methyladenosine editing with CRISPR/dCas13a in plants

Plant Biotechnol J. 2024 Jul;22(7):1867-1880. doi: 10.1111/pbi.14307. Epub 2024 Feb 16.

Abstract

N6-methyladenonsine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) and plays critical roles in mRNA processing and metabolism. However, perturbation of individual m6A modification to reveal its function and the phenotypic effects is still lacking in plants. Here, we describe the construction and characterization of programmable m6A editing tools by fusing the m6A writers, the core catalytic domain of the MTA and MTB complex, and the AlkB homologue 5 (ALKBH5) eraser, to catalytically dead Cas13a (dCas13a) to edit individual m6A sites on mRNAs. We demonstrated that our m6A editors could efficiently and specifically deposit and remove m6A modifications on specific RNA transcripts in both Nicotiana benthamiana and Arabidopsis thaliana. Moreover, we found that targeting SHORT-ROOT (SHR) transcripts with a methylation editor could significantly increase its m6A levels with limited off-target effects and promote its degradation. This leads to a boost in plant growth with enlarged leaves and roots, increased plant height, plant biomass, and total grain weight in Arabidopsis. Collectively, these findings suggest that our programmable m6A editing tools can be applied to study the functions of individual m6A modifications in plants, and may also have potential applications for future crop improvement.

Keywords: Arabidopsis; CRISPR/dCas13a; N6‐methyladenonsine; m6A editing; plant growth.

MeSH terms

  • Adenosine* / analogs & derivatives
  • Adenosine* / genetics
  • Adenosine* / metabolism
  • Arabidopsis* / genetics
  • CRISPR-Cas Systems
  • Gene Editing / methods
  • Nicotiana* / genetics
  • Nicotiana* / metabolism
  • Plants, Genetically Modified / genetics
  • RNA Editing / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Plant / genetics
  • RNA, Plant / metabolism

Substances

  • N-methyladenosine
  • Adenosine
  • RNA, Messenger
  • RNA, Plant