Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI

Neuron. 2024 Mar 6;112(5):694-697. doi: 10.1016/j.neuron.2024.01.026. Epub 2024 Feb 21.

Abstract

The iDA Project (iPSCs to Study Diversity in Alzheimer's and Alzheimer's Disease-related Dementias) is generating 200 induced pluripotent stem cell lines from Alzheimer's Disease Neuroimaging Initiative participants. These lines are sex balanced, include common APOE genotypes, span disease stages, and are ancestrally diverse. Cell lines and characterization data will be shared openly.

MeSH terms

  • Alzheimer Disease* / genetics
  • Cell Line
  • Humans
  • Induced Pluripotent Stem Cells*
  • Neuroimaging / methods