CSMed® wound dressing for prophylaxis and management of radiation dermatitis in breast and head-neck cancer patients: a single hospital prospective clinical trial

Yueh-Chun Lee; Hsien-Chun Tseng; Huei-Fang Yang; Yi-Hung Lee; Ya-Fang Ko; Shin-Tsung Chang; Hsin-Lin Chen; Bo-Jiun Chang; Ying-Hsiang Chou

doi:10.1007/s00432-024-05624-6

CSMed^® wound dressing for prophylaxis and management of radiation dermatitis in breast and head-neck cancer patients: a single hospital prospective clinical trial

J Cancer Res Clin Oncol. 2024 Feb 23;150(2):101. doi: 10.1007/s00432-024-05624-6.

Authors

Yueh-Chun Lee^{1

2}, Hsien-Chun Tseng^{3

4}, Huei-Fang Yang^{3

5}, Yi-Hung Lee³, Ya-Fang Ko^{3

5}, Shin-Tsung Chang^{3

6}, Hsin-Lin Chen³, Bo-Jiun Chang³, Ying-Hsiang Chou^{3

7}

Affiliations

¹ Department of Radiation Oncology, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., South Dist., Taichung, 40201, Taiwan. [email protected].
² School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan. [email protected].
³ Department of Radiation Oncology, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., South Dist., Taichung, 40201, Taiwan.
⁴ School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan.
⁵ Department of Nursing, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan.
⁶ Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan.
⁷ Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, 40201, Taiwan.

Abstract

Purpose: CSMed^® wound dressing, a dressing with various herb extracts, was tested for its therapeutic effect in radiation dermatitis of breast and head-and-neck cancer patients.

Methods: This study included 20 breast cancer patients and 10 head-and-neck cancer patients. Half of the irradiated area was covered with CSMed^® and the other half was under routine treatment. The severity of radiation dermatitis was evaluated with radiation therapy oncology group (RTOG) grade throughout the treatment and the follow-up period. The RTOG grade between the dressed and undressed area were compared to illustrate the therapeutic effect of CSMed^® dressing.

Results: The results showed that CSMed^® dressed area had significant lower RTOG score at 3-7 weeks and final record during the treatment, and 1-3 weeks during follow-up than undressed area.

Conclusions: This indicated that CSMed^® can delay the onset, reduce the severity, and enhance healing of radiation dermatitis. CSMed^® can be used for prophylaxis and management of radiation dermatitis.

Keywords: Breast cancer; CSMed®; Head-and-neck cancer; Radiation dermatitis; Radiotherapy.

Publication types

Clinical Trial

MeSH terms

Bandages
Breast Neoplasms* / radiotherapy
Female
Head and Neck Neoplasms* / radiotherapy
Hospitals
Humans
Prospective Studies
Radiodermatitis* / etiology
Radiodermatitis* / prevention & control