Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2

Melina Tangos; Muhammad Jarkas; Ibrahim Akin; Ibrahim El-Battrawy; Nazha Hamdani

doi:10.1016/j.mib.2024.102437

Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2

Curr Opin Microbiol. 2024 Apr:78:102437. doi: 10.1016/j.mib.2024.102437. Epub 2024 Feb 23.

Authors

Melina Tangos¹, Muhammad Jarkas¹, Ibrahim Akin², Ibrahim El-Battrawy³, Nazha Hamdani⁴

Affiliations

¹ Institute of Physiology, Department of Cellular and Translational Physiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital of the Ruhr University Bochum, Bochum, Germany.
² First Department of Medicine, University Medical Centre Mannheim (UMM), Mannheim, Germany.
³ Institute of Physiology, Department of Cellular and Translational Physiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology and Angiology, Bergmannsheil University Hospital, Ruhr University Bochum, Bochum, Germany.
⁴ Institute of Physiology, Department of Cellular and Translational Physiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital of the Ruhr University Bochum, Bochum, Germany; HCEMM-SU Cardiovascular Comorbidities Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Hungary; Department of Physiology, Cardiovascular Research Institute Maastricht University Maastricht, Maastricht, the Netherlands. Electronic address: [email protected].

PMID: 38394964
DOI: 10.1016/j.mib.2024.102437

Abstract

Until now, the World Health Organization registered over 771 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection worldwide, of which 6.97 million resulted in death. Virus-related cardiovascular events and pre-existing heart problems have been identified as major contributing factors to global infection-related morbidity and mortality, emphasizing the necessity for risk assessment and future prevention. In this review, we highlight cardiac manifestations that might arise from an infection with SARS-CoV-2 and provide an overview of known comorbidities that worsen the outcome. Additionally, we aim to summarize the therapeutic strategies proposed to reverse virus-associated myocardial damage, which will be further highlighted in this review, with an outlook to successful recovery and prevention.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Humans
SARS-CoV-2*
Tropism