Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers

Masashi Koto; Hiroaki Ikawa; Taku Inaniwa; Reiko Imai; Makoto Shinoto; Hirotoshi Takiyama; Tetsuro Isozaki; Hideyuki Mizuno; Ryosuke Kohno; Ikumi Takahashi; Naoki Yoshida; Shigeru Yamada

doi:10.1016/j.radonc.2024.110180

Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers

Radiother Oncol. 2024 May:194:110180. doi: 10.1016/j.radonc.2024.110180. Epub 2024 Feb 24.

Authors

Affiliations

¹ QST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan. Electronic address: [email protected].
² QST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan.
³ Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
⁴ Department of Radiologic Sciences, Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Tokyo, Japan.
⁵ Accelerator Engineering Corporation, Chiba, Japan.

PMID: 38403023
DOI: 10.1016/j.radonc.2024.110180

Abstract

This feasibility study confirmed the initial safety and efficacy of a novel carbon-ion radiotherapy (CIRT) using linear energy transfer (LET) painting for head and neck cancer. This study is the first step toward establishing CIRT with LET painting in clinical practice and making it a standard practice in the future.

Keywords: Carbon-ion radiotherapy; Dose-averaged LET; Head and neck cancer; LET optimization; LET painting.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Feasibility Studies*
Female
Head and Neck Neoplasms* / radiotherapy
Heavy Ion Radiotherapy* / methods
Humans
Linear Energy Transfer*
Male
Middle Aged
Radiotherapy Dosage*