Revised whole genome and DNA methylome of Mycobacterium marinum type strain ATCC 927T

Kirsi Savijoki; Paulina Deptula; Richard J Roberts; Milka Hammarén; Jari Yli-Kauhaluoma; Pekka Varmanen; Mataleena Parikka

doi:10.1128/mra.01016-23

Revised whole genome and DNA methylome of Mycobacterium marinum type strain ATCC 927^T

Microbiol Resour Announc. 2024 Apr 11;13(4):e0101623. doi: 10.1128/mra.01016-23. Epub 2024 Feb 28.

Authors

Kirsi Savijoki^{1

2}, Paulina Deptula³, Richard J Roberts⁴, Milka Hammarén^{5

6}, Jari Yli-Kauhaluoma¹, Pekka Varmanen², Mataleena Parikka⁵

Affiliations

¹ Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
² Faculty of Agriculture and Forestry, University of Helsinki, Helsinki, Finland.
³ Department of Food Science (FOOD), University of Copenhagen, Frederiksberg, Denmark.
⁴ New England Biolabs, Ipswich, Massachusetts, USA.
⁵ Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
⁶ European Molecular Biology Laboratory, Heidelberg, Germany.

Abstract

Mycobacterium marinum, a slow-growing Actinobacterium, typically induces tuberculosis-like disease in fish. Here, we report a new reference sequence for M. marinum ATCC 927^T, along with its DNA methylome. This aims to maximize the research potential of this type strain and facilitates investigations into the pathomechanisms of human tuberculosis.

Keywords: DNA methylome; Mycobacterium marinum; SMRT-PacBio; genome analysis; plasmid; tuberculosis.

Abstract

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