First Case of Necrotizing Fasciitis and Septicemia Caused by Pigmentibacter ruber

Jpn J Infect Dis. 2024 Jul 23;77(4):244-246. doi: 10.7883/yoken.JJID.2023.370. Epub 2024 Feb 29.

Abstract

We report the first case of necrotizing fasciitis caused by Pigmentibacter ruber. The isolated strain could not be identified by biochemical characterization or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry but was identified as P. ruber by 16S ribosomal RNA and whole-genome sequencing. Although much remains unknown about the pathogenicity of this bacterial species in humans, it has been shown to cause life-threatening infections such as septicemia and necrotizing fasciitis. Because the isolate was highly resistant to β-lactams, it was difficult to treat with antimicrobial therapy. Thus, further documentation of cases and analyses are required.

Keywords: Pigmentibacter ruber; necrotizing fasciitis; whole-genome sequencing.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • DNA, Bacterial / genetics
  • Fasciitis, Necrotizing* / drug therapy
  • Fasciitis, Necrotizing* / microbiology
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • RNA, Ribosomal, 16S* / genetics
  • Sepsis* / drug therapy
  • Sepsis* / microbiology
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Whole Genome Sequencing

Substances

  • RNA, Ribosomal, 16S
  • Anti-Bacterial Agents
  • DNA, Bacterial