Among others, the existence of pathophysiological biomarkers such as cerebrospinal fluid (CSF) Aβ-42, t-tau, and p-tau preceding the onset of Alzheimer's disease (AD) symptomatology has shifted the conceptualization of AD as a continuum. In addition, magnetic resonance imaging (MRI) enables the study of structural and functional cross-sectional correlates and longitudinal changes in vivo, and therefore, the combination of CSF data and imaging analyses emerges as a synergistic approach to understand the structural correlates related with specific AD-related biomarkers. In this chapter, we describe the methods used in neuroimaging that will allow researchers to combine data on CSF metabolites with imaging analyses.
Keywords: Alzheimer’s disease; Diffusion tensor imaging; Functional MRI; Imaging biomarkers; Magnetic resonance imaging; ROI-based analysis; Structural and functional connectivity; Voxel-based morphology.
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.