Hematoporphyrin monomethyl ether-mediated photodynamic therapy for acquired port-wine stain at lower extremity: Two case reports

Yawen Wang; Jun Xia; Zhao Wang; Dan Ye; Youbao Li; Die Hu; Dongqin Lei; Jun Zhou; Songmei Geng; Weihui Zeng; Jing Liu

doi:10.1016/j.pdpdt.2024.104032

Hematoporphyrin monomethyl ether-mediated photodynamic therapy for acquired port-wine stain at lower extremity: Two case reports

Photodiagnosis Photodyn Ther. 2024 Apr:46:104032. doi: 10.1016/j.pdpdt.2024.104032. Epub 2024 Mar 1.

Authors

Yawen Wang¹, Jun Xia², Zhao Wang¹, Dan Ye¹, Youbao Li¹, Die Hu¹, Dongqin Lei³, Jun Zhou¹, Songmei Geng¹, Weihui Zeng⁴, Jing Liu⁵

Affiliations

¹ Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
² Department of Dermatology, The Seventh Affiliated hospital, Sun Yat-sen University, Guangzhou, China.
³ Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and sensing, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
⁴ Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China. Electronic address: [email protected].
⁵ Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China. Electronic address: [email protected].

PMID: 38431025
DOI: 10.1016/j.pdpdt.2024.104032

Abstract

Two cases of acquired port-wine stain (APWS) at lower extremity were treated with hematoporphyrin monomethyl ether (HMME) and 532 nm LED green light-mediated photodynamic therapy (HMME-PDT). No serious adverse reactions were observed during or post-treatment period. Five-month follow-up showed significant reduction of red patches after a single HMME-PDT treatment in both cases.

Keywords: Acquired port-wine stain; HMME-PDT; Photodynamic Therapy.

Publication types

Case Reports

MeSH terms

Adult
Female
Hematoporphyrins* / therapeutic use
Humans
Lower Extremity
Male
Photochemotherapy* / methods
Photosensitizing Agents* / therapeutic use
Port-Wine Stain* / drug therapy

Substances

Hematoporphyrins
hematoporphyrin monomethyl ether
Photosensitizing Agents