[Intra-abdominal EWSR1/FUS-CREM rearranged malignant epithelioid neoplasms: report of a case]

J H Wu; S X Xu; M Xu; P Shen; J F Chen; X T Jin; H O N G Kuick; T O U E N Chang; M Z Yin

doi:10.3760/cma.j.cn112151-20231023-00286

[Intra-abdominal EWSR1/FUS-CREM rearranged malignant epithelioid neoplasms: report of a case]

Zhonghua Bing Li Xue Za Zhi. 2024 Mar 8;53(3):299-302. doi: 10.3760/cma.j.cn112151-20231023-00286.

[Article in Chinese]

Authors

J H Wu¹, S X Xu², M Xu³, P Shen¹, J F Chen¹, X T Jin¹, H O N G Kuick⁴, T O U E N Chang⁴, M Z Yin¹

Affiliations

¹ Department of Pathology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
² Department of Pathology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fuzhou 350011, China.
³ Department of Pathology, Children's Hospital Affiliated to Chongqing Medical University, Chongqing 400000, China.
⁴ Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore 229899, Singapore.

PMID: 38433061
DOI: 10.3760/cma.j.cn112151-20231023-00286

Abstract

腹腔内伴EWSR1/FUS-CREM重排恶性上皮样肿瘤是新近发现、分化不明的恶性肿瘤，形态学及免疫表型显示上皮分化，具有恶性潜能及转移倾向。本文报道1例多次复发伴肺转移的病例。镜下肿瘤界限尚清，有纤维性假包膜，肿瘤周边及细胞巢间隔见较多炎性细胞浸润，肿瘤细胞呈上皮样、多边形，胞质丰富，呈嗜酸性，核呈圆形或卵圆形，可见小核仁。肿瘤细胞上皮细胞膜抗原弥漫强阳性，广谱细胞角蛋白局灶强阳性，波形蛋白、WT1、突触素、Calretinin等阴性。分子检测示EWSR1-ATF1融合。.

Publication types

Case Reports

MeSH terms

Cyclic AMP Response Element Modulator
Humans
Neoplasms*
RNA-Binding Protein EWS / genetics
RNA-Binding Protein FUS

Substances

CREM protein, human
Cyclic AMP Response Element Modulator
EWSR1 protein, human
RNA-Binding Protein EWS
FUS protein, human
RNA-Binding Protein FUS