Surgical Margins in Musculoskeletal Sarcoma

JBJS Rev. 2024 Mar 6;12(3). doi: 10.2106/JBJS.RVW.23.00224. eCollection 2024 Mar 1.

Abstract

» Negative margin resection of musculoskeletal sarcomas is associated with reduced risk of local recurrence.» There is limited evidence to support an absolute margin width of soft tissue or bone that correlates with reduced risk of local recurrence.» Factors intrinsic to the tumor, including histologic subtype, grade, growth pattern and neurovascular involvement impact margin status and local recurrence, and should be considered when evaluating a patient's individual risk after positive margins.» Appropriate use of adjuvant therapy, critical analysis of preoperative advanced cross-sectional imaging, and the involvement of a multidisciplinary team are essential to obtain negative margins when resecting sarcomas.

MeSH terms

  • Cell Proliferation
  • Combined Modality Therapy
  • Humans
  • Margins of Excision
  • Sarcoma* / surgery
  • Soft Tissue Neoplasms* / surgery