Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual

Katharina Kocher; Carolin Moosmann; Felix Drost; Christine Schülein; Pascal Irrgang; Philipp Steininger; Jahn Zhong; Johannes Träger; Bernd Spriewald; Christoph Bock; Dirk H Busch; Christian Bogdan; Benjamin Schubert; Thomas H Winkler; Matthias Tenbusch; Ev-Marie Schuster; Kilian Schober

doi:10.1016/S1473-3099(24)00134-8

Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual

Lancet Infect Dis. 2024 May;24(5):e272-e274. doi: 10.1016/S1473-3099(24)00134-8. Epub 2024 Mar 4.

Authors

Katharina Kocher¹, Carolin Moosmann¹, Felix Drost², Christine Schülein¹, Pascal Irrgang³, Philipp Steininger³, Jahn Zhong⁴, Johannes Träger¹, Bernd Spriewald⁵, Christoph Bock⁶, Dirk H Busch⁷, Christian Bogdan⁸, Benjamin Schubert⁹, Thomas H Winkler¹⁰, Matthias Tenbusch¹¹, Ev-Marie Schuster¹, Kilian Schober¹²

Affiliations

¹ Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
² Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
³ Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁴ Department of Biology, Division of Genetics, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁵ Department of Internal Medicine 5, University Hospital Erlangen, Erlangen, Germany.
⁶ CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Medical University of Vienna, Institute of Artificial Intelligence, Center for Medical Data Science, Vienna, Austria.
⁷ Institute for Medical Microbiology, Immunology, and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany; German Center for Infection Research, Partner Site Munich, Munich, Germany.
⁸ Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; FAU Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁹ Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Department of Mathematics, Technical University of Munich, Garching bei München, Germany.
¹⁰ Department of Biology, Division of Genetics, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; FAU Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
¹¹ Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; FAU Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
¹² Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; FAU Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: [email protected].

PMID: 38452777
DOI: 10.1016/S1473-3099(24)00134-8

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptive Immunity*
COVID-19 / immunology
COVID-19 / prevention & control
COVID-19 Vaccines / administration & dosage
COVID-19 Vaccines / immunology
Humans
SARS-CoV-2 / immunology
Vaccination

Substances

COVID-19 Vaccines