Appropriateness of Use of Streptococcal Pharyngitis Testing and Associated Antibiotic Prescribing in the Urgent Care Setting

Clin Pediatr (Phila). 2024 Dec;63(12):1691-1697. doi: 10.1177/00099228241237908. Epub 2024 Mar 12.

Abstract

The primary objective was to evaluate Group A streptococcal (GAS) tests performed with a Modified Centor Criteria (MCC) Score < 3 at Urgent Care Clinics (UCC). Secondary objectives included evaluating the MCC sensitivity and specificity, antibiotics prescribed with an MCC score < 3, and association between palatal petechiae and GAS pharyngitis infections. This was a retrospective review from July 1, 2018, to June 30, 2019, of Rapid Antigen Detection Tests (RADTs) on patients with ICD codes associated with pharyngitis. Fifteen hundred patient charts were reviewed. The majority of MCC scores were < 3 at 60.0% (878/1464). Sensitivity of GAS testing (RADT/culture) slightly increased for MCC scores ≥ 3 and was better than the specificity of those scores. In comparison, MCC scores < 3, showed better specificity compared to sensitivity. Over 50% of RADTs performed were inappropriate per clinical guidelines. MCC score < 3 had higher rates of negative test results.

Keywords: group A β-hemolytic streptococcus (GAS); modified centor criteria (MCC); pharyngitis; rapid antigen detection tests (RADTs); research electronic data capture (REDCap); urgent care clinics (UCCs).

MeSH terms

  • Adolescent
  • Ambulatory Care / statistics & numerical data
  • Anti-Bacterial Agents* / therapeutic use
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Inappropriate Prescribing / prevention & control
  • Inappropriate Prescribing / statistics & numerical data
  • Male
  • Pharyngitis* / diagnosis
  • Pharyngitis* / drug therapy
  • Pharyngitis* / microbiology
  • Retrospective Studies
  • Sensitivity and Specificity
  • Streptococcal Infections* / diagnosis
  • Streptococcal Infections* / drug therapy
  • Streptococcus pyogenes*

Substances

  • Anti-Bacterial Agents