Astrocyte control of brain metastasis

Joseph M Rone; Camilo Faust Akl; Francisco J Quintana

doi:10.1016/j.devcel.2024.02.004

Astrocyte control of brain metastasis

Dev Cell. 2024 Mar 11;59(5):559-560. doi: 10.1016/j.devcel.2024.02.004.

Authors

Joseph M Rone¹, Camilo Faust Akl¹, Francisco J Quintana²

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: [email protected].

PMID: 38471436
DOI: 10.1016/j.devcel.2024.02.004

Abstract

Developing therapeutics to improve metastatic brain cancer prognosis is hampered by limited experimental systems that recapitulate the brain tumor microenvironment. In this issue of Developmental Cell, Ishibashi et al. describe a glial-cancer cell co-culture system that enabled the identification of a targetable, astrocyte-driven mechanism of brain metastasis.

MeSH terms

Astrocytes*
Brain / pathology
Brain Neoplasms* / pathology
Humans
Neuroglia
Tumor Microenvironment