Follow-up of cognitive impairment and inflammatory profile in individuals with mild COVID-19

Nathália Gualberto Souza-Silva; Daniela Valadão Rosa; Jonas Jardim de Paula; Roney Santos Coimbra; Débora Marques Miranda; Marco Aurélio Romano-Silva

doi:10.1016/j.jneuroim.2024.578327

Follow-up of cognitive impairment and inflammatory profile in individuals with mild COVID-19

J Neuroimmunol. 2024 Apr 15:389:578327. doi: 10.1016/j.jneuroim.2024.578327. Epub 2024 Mar 5.

Authors

Nathália Gualberto Souza-Silva¹, Daniela Valadão Rosa¹, Jonas Jardim de Paula², Roney Santos Coimbra³, Débora Marques Miranda⁴, Marco Aurélio Romano-Silva⁵

Affiliations

¹ Centro de Tecnologia em Medicina Molecular (CTMM), Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190, Belo Horizonte, MG, Brazil.
² Centro de Tecnologia em Medicina Molecular (CTMM), Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190, Belo Horizonte, MG, Brazil; Departamento de Psiquiatria, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
³ Neurogenômica/Imunopatologia, Instituto René Rachou, Fiocruz, Belo Horizonte, MG, Brazil.
⁴ Centro de Tecnologia em Medicina Molecular (CTMM), Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190, Belo Horizonte, MG, Brazil; Departamento de Pediatria, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
⁵ Centro de Tecnologia em Medicina Molecular (CTMM), Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190, Belo Horizonte, MG, Brazil; Departamento de Psiquiatria, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. Electronic address: [email protected].

PMID: 38489978
DOI: 10.1016/j.jneuroim.2024.578327

Abstract

Individuals who experience mild COVID-19 can suffer from long-lasting cognitive symptoms. Notably, 26% of these individuals experience difficulties with visuospatial abilities six months after infection. However, among those who initially exhibited visuoconstructive impairments, 66% showed improvement or complete reversal over time. Additionally, changes in cytokine levels, particularly CCL11, HGF, and CXCL10, were observed. These results suggest a potential link between ongoing cognitive issues and elevated levels of pro-inflammatory cytokines, which merits further investigation.

Keywords: Post-acute COVID-19 syndrome. Neuroinflammation. Cytokine. Cognitive symptoms. Visuospatial processing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / complications
Cognitive Dysfunction* / etiology
Cytokines
Follow-Up Studies
Humans

Substances

Cytokines