How transcription factor binding controls transcriptional bursting dynamics: A single-molecule view

Shasha Chong; Shawn Yoshida

doi:10.1016/j.molcel.2024.02.027

How transcription factor binding controls transcriptional bursting dynamics: A single-molecule view

Mol Cell. 2024 Mar 21;84(6):997-999. doi: 10.1016/j.molcel.2024.02.027.

Authors

Shasha Chong¹, Shawn Yoshida²

Affiliations

¹ Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: [email protected].
² Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

PMID: 38518750
DOI: 10.1016/j.molcel.2024.02.027

Abstract

In this issue, Pomp et al.¹ simultaneously tracked transcriptional bursts of yeast gene GAL10 and transient binding of transcription factor Gal4 at the gene using novel methods. Dynamic exchange and infrequent long binding of Gal4 together enable prolonged transcriptional bursts of GAL10.

MeSH terms

Gene Expression Regulation
Protein Binding
Saccharomyces cerevisiae* / genetics
Saccharomyces cerevisiae* / metabolism
Transcription Factors / genetics
Transcription Factors / metabolism
Transcription, Genetic*

Substances

Transcription Factors