Post-Transplant Lymphoproliferative Disorders

Semin Nephrol. 2024 Jan;44(1):151503. doi: 10.1016/j.semnephrol.2024.151503. Epub 2024 Mar 22.

Abstract

Post-transplant lymphoproliferative disorders (PTLDs) are a heterogenous set of unregulated lymphoid cell proliferations after organ or tissue transplant. A majority of cases are associated with the Epstein-Barr virus and higher intensity of pharmacologic immunosuppression. The clinical presentations are numerous. The diagnosis is ideally by histology, except in cases where the tumor is inaccessible to biopsy. While some pre-emptive therapies and treatment strategies are available have reasonable success are available, they do not eliminate the high morbidity and significant mortality after PTLD.

Keywords: Epstein-Barr virus; Post-transplant lymphoproliferative disorders; lymphoma; malignancy; transplant.

Publication types

  • Review

MeSH terms

  • Epstein-Barr Virus Infections* / complications
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Immunosuppression Therapy / adverse effects
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation / adverse effects
  • Lymphoproliferative Disorders* / etiology
  • Organ Transplantation / adverse effects
  • Postoperative Complications / etiology

Substances

  • Immunosuppressive Agents