Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance: Big data in smaller bodies

Michael P DiLorenzo; Simon Lee; Rahul H Rathod; Francesca Raimondi; Kanwal M Farooqi; Supriya S Jain; Margaret M Samyn; Tiffanie R Johnson; Laura J Olivieri; Mark A Fogel; Wyman W Lai; Pierangelo Renella; Andrew J Powell; Sujatha Buddhe; Caitlin Stafford; Jason N Johnson; Willem A Helbing; Kuberan Pushparajah; Inga Voges; Vivek Muthurangu; Kimberley G Miles; Gerald Greil; Colin J McMahon; Timothy C Slesnick; Brian M Fonseca; Shaine A Morris; Jonathan H Soslow; Lars Grosse-Wortmann; Rebecca S Beroukhim; Heynric B Grotenhuis

doi:10.1016/j.jocmr.2024.101041

Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance: Big data in smaller bodies

J Cardiovasc Magn Reson. 2024;26(1):101041. doi: 10.1016/j.jocmr.2024.101041. Epub 2024 Mar 23.

Authors

Michael P DiLorenzo¹, Simon Lee², Rahul H Rathod³, Francesca Raimondi⁴, Kanwal M Farooqi⁵, Supriya S Jain⁶, Margaret M Samyn⁷, Tiffanie R Johnson⁸, Laura J Olivieri⁹, Mark A Fogel¹⁰, Wyman W Lai¹¹, Pierangelo Renella¹², Andrew J Powell¹³, Sujatha Buddhe¹⁴, Caitlin Stafford¹⁵, Jason N Johnson¹⁶, Willem A Helbing¹⁷, Kuberan Pushparajah¹⁸, Inga Voges¹⁹, Vivek Muthurangu²⁰, Kimberley G Miles²¹, Gerald Greil²², Colin J McMahon²³, Timothy C Slesnick²⁴, Brian M Fonseca²⁵, Shaine A Morris²⁶, Jonathan H Soslow²⁷, Lars Grosse-Wortmann²⁸, Rebecca S Beroukhim²⁹, Heynric B Grotenhuis³⁰

Affiliations

¹ Division of Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian Morgan Stanley Children's Hospital, 3959 Broadway, New York, NY 10032, USA. Electronic address: [email protected].
² Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. Electronic address: [email protected].
³ Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: [email protected].
⁴ Congenital Cardiology Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy. Electronic address: [email protected].
⁵ Division of Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian Morgan Stanley Children's Hospital, 3959 Broadway, New York, NY 10032, USA. Electronic address: [email protected].
⁶ New York Medical College/Maria Fareri Children's Hospital at Westchester Medical Center, 100 Woods Rd, Valhalla, NY 10595, USA. Electronic address: [email protected].
⁷ Medical College of Wisconsin/The Herma Heart Institute at Children's Wisconsin, 8915 W Connell Ct, Milwaukee, WI 53226, USA. Electronic address: [email protected].
⁸ Indiana University School of Medicine, Riley Children's Health, 705 Riley Hospital Drive, Indianapolis, IN 46202, USA. Electronic address: [email protected].
⁹ Department of Pediatric Cardiology, Children's Hospital of Pittsburgh, Children's Hospital Drive, 4401 Penn Ave, Pittsburgh, PA 15224, USA. Electronic address: [email protected].
¹⁰ Division of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104, USA. Electronic address: [email protected].
¹¹ CHOC Children's Hospital, 1201 W La Veta Ave, Orange, CA 92868, USA. Electronic address: [email protected].
¹² CHOC Children's Hospital, 1201 W La Veta Ave, Orange, CA 92868, USA. Electronic address: [email protected].
¹³ Boston Children's Hospital, Boston, MA 02115, USA.
¹⁴ Department of Pediatrics, Division of Pediatric Cardiology, Betty Irene Moore Heart Center, Lucile Packard Children's Hospital, 725 Welch Rd Ste 325, Palo Alto, CA 94304, USA. Electronic address: [email protected].
¹⁵ Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: [email protected].
¹⁶ Department of Pediatrics, University of Tennessee Health Sciences Center, 848 Adams Ave, Memphis, TN 38103, USA; Division of Pediatric Cardiology, Le Bonheur Children's Hospital, University of Tennessee Health Sciences Center, 848 Adams Ave, Memphis, TN 38103, USA. Electronic address: [email protected].
¹⁷ Department of Pediatrics, Division of Pediatric Cardiology, Sophia's Children's Hospital, Erasmus University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, Rotterdam, the Netherlands. Electronic address: [email protected].
¹⁸ Department of Paediatric Cardiology, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, United Kingdom. Electronic address: [email protected].
¹⁹ German Centre for Cardiovascular Research, Ootsdamer Str. 58, 10785 Berlin, Germany; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Arnold-Heller-Straße 3, 24105 Kiel, Germany. Electronic address: [email protected].
²⁰ UCL Center for Translational Cardiovascular Imaging, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: [email protected].
²¹ Heart Institute, Cincinnati Children's Hospital Medical Center, 333 Burnet Ave, Kimberley, Cincinnati, OH 45229, USA. Electronic address: [email protected].
²² Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address: [email protected].
²³ University College of Dublin, School of Medicine and Department of Paediatric Cardiology, Children's Health Ireland, Gate 5, Crumlin, Dublin 12, Ireland. Electronic address: [email protected].
²⁴ Department of Pediatrics, Division of Pediatric Cardiology, Emory University School of Medicine, 738 Old Norcross Road, Lawrenceville, GA 30046, USA; Department of Pediatrics, Division of Pediatric Cardiology, Children's Healthcare of Atlanta, Atlanta, Georgia, Division of Pediatric Cardiology, Emory University School of Medicine, 738 Old Norcross Road, Lawrenceville, GA 30046, USA. Electronic address: [email protected].
²⁵ Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Ave, Aurora, CO 80045, USA. Electronic address: [email protected].
²⁶ Division of Cardiology, Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital, 6651 Main Street, Houston, TX 77030, USA. Electronic address: [email protected].
²⁷ Department of Pediatrics, Division of Pediatric Cardiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA. Electronic address: [email protected].
²⁸ Division of Cardiology, Department of Pediatrics, Doernbecher Children's Hospital, Oregon Health and Science University, 700 SW Campus Dr, Portland, OR, USA 97239. Electronic address: [email protected].
²⁹ Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: [email protected].
³⁰ Pediatric Cardiology, Wilhelmina Children's Hospital, UMCU, Lundlaan 6, 3584 EA Utrecht, the Netherlands. Electronic address: [email protected].

Abstract

Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.

Keywords: CMR; Multicenter studies; Pediatric and congenital heart disease; Research.

Publication types

Review

MeSH terms

Adolescent
Age Factors
Big Data
Child
Child, Preschool
Heart Defects, Congenital* / diagnostic imaging
Heart Defects, Congenital* / physiopathology
Humans
Magnetic Resonance Imaging
Multicenter Studies as Topic*
Predictive Value of Tests*
Research Design