How To Report the Minor Component of a High-grade Pattern in Radical Prostatectomy Specimens: Time To Abandon the "Tertiary" Terminology?

Alessia Cimadamore; Gianluca Giannarini; Alessandro Crestani; Antonio Lopez-Beltran; Rodolfo Montironi; Liang Cheng

doi:10.1016/j.eururo.2024.02.017

How To Report the Minor Component of a High-grade Pattern in Radical Prostatectomy Specimens: Time To Abandon the "Tertiary" Terminology?

Eur Urol. 2024 Oct;86(4):291-294. doi: 10.1016/j.eururo.2024.02.017. Epub 2024 Mar 27.

Authors

Alessia Cimadamore¹, Gianluca Giannarini², Alessandro Crestani², Antonio Lopez-Beltran³, Rodolfo Montironi⁴, Liang Cheng⁵

Affiliations

¹ Institute of Pathological Anatomy, Department of Medicine, University of Udine, via Chiusaforte, 33100 Udine, Italy. Electronic address: [email protected].
² Urology Unit, Santa Maria della Misericordia University Hospital, Udine, Italy.
³ Department of Surgery, Cordoba University Medical School, Cordoba, Spain.
⁴ Molecular Medicine and Cell Therapy Foundation, Polytechnic University of the Marche Region, Ancona, Italy.
⁵ Department of Pathology and Laboratory Medicine, Department of Surgery/Urology, Brown University Warren Alpert Medical School, Lifespan Academic Medical Center; Legorreta Cancer Center at Brown University, 222 Richmond St, Providence, RI, 02903, USA. Electronic address: [email protected].

PMID: 38548491
DOI: 10.1016/j.eururo.2024.02.017

Abstract

The International Society of Urological Pathology and Genitourinary Pathology Society differ in their recommendations for reporting of minor components of high-grade pattern in prostatectomy specimens. This can affect the grade group assigned, particularly when there are only two Gleason patterns in a cancer nodule. We therefore argue that the term "tertiary" should be changed to "minor" component.

Publication types

Editorial

MeSH terms

Humans
Male
Neoplasm Grading*
Prostatectomy* / methods
Prostatic Neoplasms* / pathology
Prostatic Neoplasms* / surgery
Terminology as Topic*