Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments?

ACS Chem Neurosci. 2024 Apr 17;15(8):1609-1610. doi: 10.1021/acschemneuro.4c00133. Epub 2024 Mar 29.

Abstract

Amylin is a neuroendocrine hormone with a potential role in addictive disorders, including alcohol use disorder (AUD). In addition to reducing appetitive behavior, amylin has been shown to affect alcohol-related behaviors in rodents. Delineating the biobehavioral correlates of amylin in relation to alcohol seeking and consumption has the potential of identifying new treatment targets for AUD, yet additional translational and human research is needed.

Keywords: Amylin; addiction; alcohol; calcitonin; dopamine; serotonin.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Alcoholism* / drug therapy
  • Behavior, Addictive*
  • Ethanol
  • Humans
  • Islet Amyloid Polypeptide
  • Peptide Hormones*

Substances

  • Islet Amyloid Polypeptide
  • Ethanol
  • Peptide Hormones