APOE loss of function: A genetic shield against Alzheimer's disease

Mason D Tate; Hande Karahan; Jungsu Kim

doi:10.1016/j.neuron.2024.03.003

APOE loss of function: A genetic shield against Alzheimer's disease

Neuron. 2024 Apr 3;112(7):1033-1035. doi: 10.1016/j.neuron.2024.03.003.

Authors

Mason D Tate¹, Hande Karahan², Jungsu Kim³

Affiliations

¹ Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN, USA.
² Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
³ Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: [email protected].

PMID: 38574724
DOI: 10.1016/j.neuron.2024.03.003

Abstract

In this issue of Neuron, Chemparathy et al.¹ provide human genetics data suggesting that APOE loss-of-function mutations may confer resistance to Alzheimer's disease (AD) without compromising longevity. These data strongly support the APOE toxic gain-of-function hypothesis for AD.

MeSH terms

Alzheimer Disease* / genetics
Apolipoprotein E4 / genetics
Apolipoproteins E / genetics
Humans
Mutation / genetics

Substances

Apolipoprotein E4
Apolipoproteins E