Chronic rhinosinusitis possibly associated with decreased lung function in chronic cough patients

Pengfei Zhao; Shin Kariya; Takaya Higaki; Seiichiro Makihara; Toru Rikimaru; Mitsuhiro Okano; Mizuo Ando

doi:10.1016/j.bjorl.2024.101424

Chronic rhinosinusitis possibly associated with decreased lung function in chronic cough patients

Braz J Otorhinolaryngol. 2024 Jul-Aug;90(4):101424. doi: 10.1016/j.bjorl.2024.101424. Epub 2024 Mar 21.

Authors

Pengfei Zhao¹, Shin Kariya², Takaya Higaki³, Seiichiro Makihara³, Toru Rikimaru⁴, Mitsuhiro Okano⁵, Mizuo Ando³

Affiliations

¹ Okayama University Academic Field of Medicine, Dentistry and Pharmaceutical Sciences, Department of Otolaryngology-Head and Neck Surgery, Okayama, Japan. Electronic address: [email protected].
² Okayama University Academic Field of Medicine, Dentistry and Pharmaceutical Sciences, Department of Otolaryngology-Head and Neck Surgery, Okayama, Japan; Kawasaki Medical School, Department of Otolaryngology-Head and Neck Surgery, Kurashiki, Japan.
³ Okayama University Academic Field of Medicine, Dentistry and Pharmaceutical Sciences, Department of Otolaryngology-Head and Neck Surgery, Okayama, Japan.
⁴ Fukuoka Sanno Hospital, Division of Respiratory Medicine, Fukuoka, Japan.
⁵ Okayama University Academic Field of Medicine, Dentistry and Pharmaceutical Sciences, Department of Otolaryngology-Head and Neck Surgery, Okayama, Japan; International University of Health and Welfare School of Medicine, Department of Otorhinolaryngology, Narita, Japan.

Abstract

Objectives: The purpose of this study is to investigate the lung function in Chronic Rhinosinusitis (CRS) patients with Chronic Cough (CC).

Methods: A total of 1413 CC patients were retrospectively screened and 109 CRS patients with CC were enrolled. Lung function, Lund-Mackay Computed Tomography (CT) score, smoking status, peripheral blood eosinophil count, and immunoglobulin E concentration in serum samples, and Sino-Nasal Outcome Test were examined. Normal control subjects are also recruited.

Results: The Forced Expiratory Volume in 1 second (FEV_1.0), Percent Predicted FEV_1.0, and FEV_1.0/Forced Vital Capacity (FVC) ratio in the patients were significantly low as compared with the control subjects. The FEV_1.0/FVC ratio was negatively correlated with the Lund-Mackay CT scores of the patients with a high CT score.

Conclusions: The CRS patients with CC should be investigated with lung function. In addition, the multidisciplinary evaluation including a pulmonologist is needed to manage the CRS patients with CC.

Level of evidence: Level 4.

Keywords: Asthma; Cough; Pulmonary function; Rhinitis; Sinusitis.

MeSH terms

Adult
Aged
Case-Control Studies
Chronic Cough
Chronic Disease
Cough* / etiology
Cough* / physiopathology
Female
Forced Expiratory Volume / physiology
Humans
Immunoglobulin E / blood
Lung / diagnostic imaging
Lung / physiopathology
Male
Middle Aged
Respiratory Function Tests
Retrospective Studies
Rhinitis* / complications
Rhinitis* / physiopathology
Rhinosinusitis
Sinusitis* / complications
Sinusitis* / physiopathology
Tomography, X-Ray Computed*
Vital Capacity / physiology
Young Adult

Substances

Immunoglobulin E