Extramammary Paget disease. Part II. Evidence-based approach to management

Rohan R Shah; Kalee Shah; Britney N Wilson; Mario M Leitao; Jan Smogorzewski; Kevin A Nguyen; Christopher Crane; Samuel A Funt; Sharif Hosein; Mirabel Dafinone; Anthony Rossi

doi:10.1016/j.jaad.2023.07.1052

Extramammary Paget disease. Part II. Evidence-based approach to management

J Am Acad Dermatol. 2024 Sep;91(3):421-430. doi: 10.1016/j.jaad.2023.07.1052. Epub 2024 Apr 6.

Authors

Affiliations

¹ Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey.
² Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.
³ Department of Gynecology, Memorial Sloan Kettering Cancer Center, New York, New York.
⁴ Department of Dermatology, UCLA Medical Center, Los Angeles, California.
⁵ Department of Dermatology, West Virginia University, Morgantown, West Virginia.
⁶ Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
⁷ Department of Urologic Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
⁸ Department of Dermatology, Memorial Sloan Kettering Cancer Center, New York, New York.
⁹ Department of Dermatology, University of Nevada, Reno School of Medicine, Reno, Nevada.
¹⁰ Department of Dermatology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: [email protected].

PMID: 38588817
DOI: 10.1016/j.jaad.2023.07.1052

Abstract

Extramammary Paget disease is a rare cutaneous malignancy that most commonly affects the genitals, perianal area, and axilla of elderly patients. Delays in care often lead to high levels of disease burden for patients. Thus, evidence-based recommendations are paramount in mitigating morbidity and mortality for this unique patient population. This 2-part continuing medical education series provides a complete picture of extramammary Paget disease. Part 2 of this continuing medical education series focuses on the complex management of extramammary Paget disease including surgical and noninvasive therapies, as well as novel approaches for advanced disease.

Keywords: Extramammary Paget disease; Mohs micrographic surgery; imiquimod; margin control; photodynamic therapy; radiation therapy.

Publication types

Review

MeSH terms

Evidence-Based Medicine*
Female
Humans
Male
Paget Disease, Extramammary* / diagnosis
Paget Disease, Extramammary* / pathology
Paget Disease, Extramammary* / therapy
Skin Neoplasms / pathology
Skin Neoplasms / therapy