Abstract
Acute liver failure, commonly caused by acetaminophen overdose, is associated with numerous systemic complications including cerebral edema, hypotension, acute kidney injury, and infection. Management is primarily supportive, with an emphasis on excellent neurocritical care. Although some antidotes and targeted treatments exist, the only definitive treatment remains orthotopic liver transplant.
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MeSH terms
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Acetaminophen* / adverse effects
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Acute Kidney Injury / chemically induced
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Acute Kidney Injury / diagnosis
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Acute Kidney Injury / etiology
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Acute Kidney Injury / therapy
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Analgesics, Non-Narcotic / adverse effects
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Antidotes
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Brain Edema / etiology
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Brain Edema / therapy
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Drug Overdose / therapy
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Humans
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Liver Failure, Acute* / chemically induced
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Liver Failure, Acute* / diagnosis
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Liver Failure, Acute* / therapy
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Liver Transplantation*
Substances
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Acetaminophen
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Analgesics, Non-Narcotic
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Antidotes