Recent advances in liquid biopsy of central nervous system lymphomas: case presentations and review of the literature

Manabu Natsumeda; Satoshi Shibuma; Haruhiko Takahashi; Jotaro On; Yoshihiro Mouri; Kaoru Tomikawa; Hidemoto Fujiwara; Jun Watanabe; Yoshihiro Tsukamoto; Masayasu Okada; Rui Takeda; Hiroshi Shimizu; Jun Takizawa; Akiyoshi Kakita; Makoto Oishi

doi:10.1007/s10014-024-00483-y

Recent advances in liquid biopsy of central nervous system lymphomas: case presentations and review of the literature

Brain Tumor Pathol. 2024 Apr;41(2):85-91. doi: 10.1007/s10014-024-00483-y. Epub 2024 Apr 10.

Authors

Affiliations

¹ Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan. [email protected].
² Advanced Treatment of Neurological Diseases Branch, Brain Research Institute, Niigata University, Niigata, Japan. [email protected].
³ Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
⁴ Department of Neurosurgery, Niigata Prefectural Central Hospital, Joetsu, Japan.
⁵ Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
⁶ Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.

PMID: 38597999
DOI: 10.1007/s10014-024-00483-y

Abstract

Surgical biopsy is the gold standard for diagnosing central nervous system (CNS) lymphomas. However, reliable liquid biopsy methods for diagnosing CNS lymphomas have quickly developed and have been implicated in clinical decision-making. In the current report, we introduce two patients for whom liquid biopsy was essential for diagnosing CNS lymphomas and discuss the rapidly growing applications of this technology.

Keywords: Central nervous system lymphomas; Droplet digital PCR; Liquid biopsy.

Publication types

Case Reports
Review

MeSH terms

Aged
Central Nervous System Neoplasms* / diagnosis
Central Nervous System Neoplasms* / pathology
Female
Humans
Liquid Biopsy / methods
Lymphoma / diagnosis
Lymphoma / pathology
Male

Grants and funding

21KK0156/Japan Society for the Promotion of Science