Gums make IL-23, no professionals needed

Mandy J McGeachy

doi:10.1016/j.immuni.2024.03.009

Gums make IL-23, no professionals needed

Immunity. 2024 Apr 9;57(4):832-834. doi: 10.1016/j.immuni.2024.03.009.

Author

Mandy J McGeachy¹

Affiliation

¹ Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA. Electronic address: [email protected].

PMID: 38599173
DOI: 10.1016/j.immuni.2024.03.009

Abstract

IL-23 activates pathogenic Th17 cells to drive inflammatory disease at barrier surfaces. Kim et al. now identify oral epithelial cells as the critical producers of IL-23 in human and mouse periodontitis, linking microbial dysbiosis to non-hematopoietic regulation of IL-17-associated inflammation.

MeSH terms

Animals
Dysbiosis
Epithelial Cells / pathology
Humans
Inflammation* / pathology
Interleukin-23
Mice
Periodontitis*
Th17 Cells / pathology

Substances

Interleukin-23