Hostile bile limits anti-cancer immunity

Pavitha Parathan; Lisa A Mielke

doi:10.1016/j.immuni.2024.03.006

Hostile bile limits anti-cancer immunity

Immunity. 2024 Apr 9;57(4):834-836. doi: 10.1016/j.immuni.2024.03.006.

Authors

Pavitha Parathan¹, Lisa A Mielke²

Affiliations

¹ Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, VIC, Australia; La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia.
² Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, VIC, Australia; La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia. Electronic address: [email protected].

PMID: 38599174
DOI: 10.1016/j.immuni.2024.03.006

Abstract

Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8⁺ T cell responses via dysregulation of calcium efflux.

MeSH terms

Apoptosis
Bile
Bile Acids and Salts
Deoxycholic Acid*
Humans
Neoplasms*

Substances

Deoxycholic Acid
Bile Acids and Salts