Myocardial Infarction with Non-obstructive Coronary Arteries Complicated by a Ventricular Septal Rupture: The Challenge of Achieving Hemodynamic Stability Using Impella Devices

Intern Med. 2024 Nov 15;63(22):3065-3070. doi: 10.2169/internalmedicine.2945-23. Epub 2024 Apr 9.

Abstract

The prognosis of myocardial infarction with non-obstructive coronary arteries (MINOCA) is reported to be as worse as myocardial infarction with obstructive coronary arteries. However, its mechanical complications are still poorly understood. A 71-year-old woman developed MINOCA after ascending aortic replacement surgery. During treatment, the patient experienced cardiogenic shock due to a ventricular septal rupture (VSR). The introduction of Impella devices reduced the left-to-right shunt and improved the patient's hemodynamics. Finally, a scheduled surgical repair was performed under stable conditions. In this report, we focused on the pathophysiology of MINOCA-related VSR and discussed the effectiveness of Impella devices as a bridge to surgical repair and circulatory backup during the perioperative period.

Keywords: STEMI; cardiogenic shock; left ventricular assist device; mechanical complication; ventricular septal defect.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Coronary Vessels / diagnostic imaging
  • Coronary Vessels / physiopathology
  • Female
  • Heart-Assist Devices*
  • Hemodynamics* / physiology
  • Humans
  • Myocardial Infarction* / complications
  • Myocardial Infarction* / etiology
  • Myocardial Infarction* / physiopathology
  • Shock, Cardiogenic / etiology
  • Shock, Cardiogenic / therapy
  • Ventricular Septal Rupture* / diagnosis
  • Ventricular Septal Rupture* / etiology
  • Ventricular Septal Rupture* / surgery
  • Ventricular Septal Rupture* / therapy