Efficacy of a high concentration of nano silver fluoride in preventing caries: A randomized controlled trial

Juliane-Rolim de Lavôr; Rodolfo-Sinésio-Amador de Abreu; Samylla-Glória-de Araújo Costa; Débora-Heloísa-Silva de Brito; Thaysa-Gomes-Ferreira-Tenório Dos Santos; Nathalia-Kelly-Veloso-de Lima Almeida; Mabel-Cristina-Paiva-Machado da Silva; Arnaldo-de França-Caldas Júnior; Mônica-Vilela Heimer; André Galembeck; Aronita Rosenblatt

doi:10.4317/jced.60776

Efficacy of a high concentration of nano silver fluoride in preventing caries: A randomized controlled trial

J Clin Exp Dent. 2024 Mar 1;16(3):e263-e269. doi: 10.4317/jced.60776. eCollection 2024 Mar.

Affiliations

¹ DDS, MSc, PhD student. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Recife, Pernambuco, Brazil.
² DDS, MSc. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Recife, Pernambuco, Brazil.
³ DDS, MSc student. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Recife, Pernambuco, Brazil.
⁴ DDS, MSc, PhD. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Recife, Pernambuco, Brazil.
⁵ DDS, PhD, Professor. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Recife, Pernambuco, Brazil.
⁶ DDS, PhD, Professor. Federal University of Pernambuco - Chemistry Department, Recife, Pernambuco, Brazil.

Abstract

Background: To investigate the effectiveness of a novel agent containing Nano Silver Fluoride 1500 (NSF 1500) and chitosan to inactivate carious lesions in children.

Material and methods: The study included eighty children. While both groups had fluoride dentifrice applied to their teeth, only the experimental group received treatment with the NSF 1500-ppm solution. The first and sixth-month interval examinations were conducted by two calibrated dentists (k = 0.85).

Results: The NSF 1500 group had 69.2% of their teeth with arrested decay, while the control group had 24.1%. The difference was statistically significant (p 0.001), with a preventive fraction of 59.4%. The number needed to treat (NNT) was approximately two. The NSF 1500 formulation was more effective than toothbrushing alone with fluoridated dentifrice in preventing dental caries.

Conclusions: The effectiveness of NSF 1500 is determined by the size and depth of the dental cavity. Its ability to arrest caries lesions was comparable to previously tested products, NSF 400 and NSF 600. Key words:Preventive dentistry, dental caries, nanoparticles.