The STRAT-PARK cohort: A personalized initiative to stratify Parkinson's disease

Kjersti Eline Stige; Simon Ulvenes Kverneng; Soumya Sharma; Geir-Olve Skeie; Erika Sheard; Mona Søgnen; Solveig Af Geijerstam; Therese Vetås; Anne Grete Wahlvåg; Haakon Berven; Sagar Buch; David Reese; Dina Babiker; Yekta Mahdi; Trevor Wade; Gala Prado Miranda; Jacky Ganguly; Yokhesh Krishnasamy Tamilselvam; Jia Ren Chai; Saurabh Bansal; Dorian Aur; Sima Soltani; Scott Adams; Christian Dölle; Fiona Dick; Erik Magnus Berntsen; Renate Grüner; Njål Brekke; Frank Riemer; Pål Erik Goa; Kristoffer Haugarvoll; E Mark Haacke; Mandar Jog; Charalampos Tzoulis

doi:10.1016/j.pneurobio.2024.102603

The STRAT-PARK cohort: A personalized initiative to stratify Parkinson's disease

Prog Neurobiol. 2024 May:236:102603. doi: 10.1016/j.pneurobio.2024.102603. Epub 2024 Apr 10.

Authors

Kjersti Eline Stige¹, Simon Ulvenes Kverneng², Soumya Sharma³, Geir-Olve Skeie⁴, Erika Sheard⁵, Mona Søgnen⁵, Solveig Af Geijerstam⁵, Therese Vetås⁵, Anne Grete Wahlvåg⁶, Haakon Berven², Sagar Buch⁷, David Reese⁸, Dina Babiker⁹, Yekta Mahdi⁹, Trevor Wade¹⁰, Gala Prado Miranda⁹, Jacky Ganguly⁹, Yokhesh Krishnasamy Tamilselvam¹¹, Jia Ren Chai⁹, Saurabh Bansal⁹, Dorian Aur⁹, Sima Soltani³, Scott Adams¹², Christian Dölle², Fiona Dick², Erik Magnus Berntsen¹³, Renate Grüner¹⁴, Njål Brekke¹⁵, Frank Riemer¹⁶, Pål Erik Goa¹⁷, Kristoffer Haugarvoll⁵, E Mark Haacke¹⁸, Mandar Jog³, Charalampos Tzoulis¹⁹

Affiliations

¹ Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway; Department of Clinical Medicine, University of Bergen, Pb 7804, Bergen 5020, Norway; K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Pb 7804, Bergen 5020, Norway; The Department of Neuromedicine and Movement Sciences, Norwegian University of Science and Technology, Trondheim 7491, Norway; Department of Neurology and Clinical Neurophysiology, St Olav's University Hospital, Trondheim 7006, Norway.
² Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway; Department of Clinical Medicine, University of Bergen, Pb 7804, Bergen 5020, Norway; K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Pb 7804, Bergen 5020, Norway.
³ Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway; Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON N6A 5A5, Canada.
⁴ Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway; Department of Clinical Medicine, University of Bergen, Pb 7804, Bergen 5020, Norway.
⁵ Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.
⁶ Department of Neurology and Clinical Neurophysiology, St Olav's University Hospital, Trondheim 7006, Norway.
⁷ Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA.
⁸ Imaging Research Laboratories, Robarts Research Institute, Ontario, London N6A 5B7, Canada.
⁹ Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON N6A 5A5, Canada.
¹⁰ Department of Medical Biophysics, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, Ontario, London N6A 6B7, Canada.
¹¹ Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON N6A 5A5, Canada; Department of Electrical and Computer Engineering, Canadian Surgical Technologies and Advanced Robotics (CSTAR), University of Western Ontario (UWO), Ontario, London, Canada.
¹² Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway; Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON N6A 5A5, Canada; School of Communication Sciences & Disorders, Faculty of Health Sciences, Western University, Canada.
¹³ Department of Radiology and Nuclear Medicine, St. Olav's University Hospital, Trondheim 7006, Norway; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim 7491, Norway.
¹⁴ Department of Physics and Technology, University of Bergen, Bergen 5007, Norway; Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Post Office Box 1400, Bergen 5021, Norway.
¹⁵ Department of Physics and Technology, University of Bergen, Bergen 5007, Norway; Radiology Department, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.
¹⁶ Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway; Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Post Office Box 1400, Bergen 5021, Norway.
¹⁷ Department of Radiology and Nuclear Medicine, St. Olav's University Hospital, Trondheim 7006, Norway; Department of Physics, Norwegian University of Science and Technology, Trondheim 7491, Norway.
¹⁸ Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA; Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA.
¹⁹ Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway; Department of Clinical Medicine, University of Bergen, Pb 7804, Bergen 5020, Norway; K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Pb 7804, Bergen 5020, Norway. Electronic address: [email protected].

PMID: 38604582
DOI: 10.1016/j.pneurobio.2024.102603

Abstract

The STRAT-PARK initiative aims to provide a platform for stratifying Parkinson's disease (PD) into biological subtypes, using a bottom-up, multidisciplinary biomarker-based and data-driven approach. PD is a heterogeneous entity, exhibiting high interindividual clinicopathological variability. This diversity suggests that PD may encompass multiple distinct biological entities, each driven by different molecular mechanisms. Molecular stratification and identification of disease subtypes is therefore a key priority for understanding and treating PD. STRAT-PARK is a multi-center longitudinal cohort aiming to recruit a total of 2000 individuals with PD and neurologically healthy controls from Norway and Canada, for the purpose of identifying molecular disease subtypes. Clinical assessment is performed annually, whereas biosampling, imaging, and digital and neurophysiological phenotyping occur every second year. The unique feature of STRAT-PARK is the diversity of collected biological material, including muscle biopsies and platelets, tissues particularly useful for mitochondrial biomarker research. Recruitment rate is ∼150 participants per year. By March 2023, 252 participants were included, comprising 204 cases and 48 controls. STRAT-PARK is a powerful stratification initiative anticipated to become a global research resource, contributing to personalized care in PD.

Keywords: Parkinson’s disease; mitochondria; progression; stratification; subtypes.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers
Canada
Cohort Studies
Female
Humans
Longitudinal Studies
Male
Middle Aged
Norway
Parkinson Disease* / diagnosis
Parkinson Disease* / physiopathology
Precision Medicine / methods

Substances

Biomarkers