MR Imaging-based Biomarker Development in Hemorrhagic Stroke Patients Including Brain Iron Quantification, Diffusion Tensor Imaging, and Phenomenon of Ultra-early Erythrolysis

Momodou G Bah; Ehsan Dowlati; Max Fleigner; Sravanthi Koduri; Aditya Pandey; Leanne Y Lin; Thomas L Chenevert; Jonathan Troost; Guohua Xi; Richard Keep; Neeraj Chaudhary

doi:10.1016/j.nic.2024.01.001

MR Imaging-based Biomarker Development in Hemorrhagic Stroke Patients Including Brain Iron Quantification, Diffusion Tensor Imaging, and Phenomenon of Ultra-early Erythrolysis

Neuroimaging Clin N Am. 2024 May;34(2):215-224. doi: 10.1016/j.nic.2024.01.001. Epub 2024 Feb 10.

Authors

Affiliations

¹ Michigan State University College of Human Medicine, Lansing, MI, USA.
² Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
³ Oakland University, William Beaumont School of Medicine, Detroit, MI, USA.
⁴ Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
⁵ Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
⁶ Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109, USA.
⁷ Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

PMID: 38604706
DOI: 10.1016/j.nic.2024.01.001

Abstract

This review article discusses the role of MR imaging-based biomarkers in understanding and managing hemorrhagic strokes, focusing on intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage. ICH is a severe type of stroke with high mortality and morbidity rates, primarily caused by the rupture of small blood vessels in the brain, resulting in hematoma formation. MR imaging-based biomarkers, including brain iron quantification, ultra-early erythrolysis detection, and diffusion tensor imaging, offer valuable insights for hemorrhagic stroke management. These biomarkers could improve early diagnosis, risk stratification, treatment monitoring, and patient outcomes in the future, revolutionizing our approach to hemorrhagic strokes.

Keywords: Early and late brain injury; Early erythrolysis; Hematomal and perihematomal iron concentration; ICH; Iron toxicity; MR imaging biomarkers; SAH; White matter injury.

Publication types

Review

MeSH terms

Biomarkers
Brain / diagnostic imaging
Cerebral Hemorrhage / complications
Cerebral Hemorrhage / diagnostic imaging
Diffusion Tensor Imaging
Hemorrhagic Stroke*
Humans
Iron
Magnetic Resonance Imaging
Stroke* / diagnostic imaging

Substances

Iron
Biomarkers