Combination therapies with ponatinib and asciminib in a preclinical model of chronic myeloid leukemia blast crisis with compound mutations

MeSH terms

• Animals
• Antineoplastic Combined Chemotherapy Protocols / therapeutic use
• Blast Crisis* / drug therapy
• Blast Crisis* / genetics
• Blast Crisis* / pathology
• Fusion Proteins, bcr-abl / genetics
• Humans
• Imidazoles* / administration & dosage
• Imidazoles* / therapeutic use
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / genetics
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / pathology
• Mice
• Mutation*
• Niacinamide / analogs & derivatives
• Protein Kinase Inhibitors / pharmacology
• Protein Kinase Inhibitors / therapeutic use
• Pyrazoles
• Pyridazines* / administration & dosage
• Pyridazines* / therapeutic use