Novel IKZF1 rearrangement identified in a patient with blastic plasmacytoid dendritic cell neoplasm decreased haematopoietic stem cell function and promoted plasmacytoid dendritic cell abnormality

Le Yin; Qian Yu; Huifang Zhang; Hongkai Zhu; Zeyu Deng; Cheng Xing; Peilong Wang; Xiangju Zeng; Zhao Cheng; Yue Sheng; Hongling Peng

doi:10.1111/bjh.19429

Novel IKZF1 rearrangement identified in a patient with blastic plasmacytoid dendritic cell neoplasm decreased haematopoietic stem cell function and promoted plasmacytoid dendritic cell abnormality

Br J Haematol. 2024 Jun;204(6):2496-2500. doi: 10.1111/bjh.19429. Epub 2024 Apr 15.

Authors

Le Yin^{1

2

3}, Qian Yu¹, Huifang Zhang^{1

2

3}, Hongkai Zhu^{1

2

3}, Zeyu Deng^{1

2

3}, Cheng Xing^{1

2

3}, Peilong Wang^{1

2

3}, Xiangju Zeng⁴, Zhao Cheng^{1

2

3}, Yue Sheng^{1

2

3}, Hongling Peng^{1

2

3

5}

Affiliations

¹ Division of Hematology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Institute of Molecular Hematology, Central South University, Changsha, Hunan, China.
³ Hunan Engineering Research Center of Cell Immunotherapy for Hematopoietic Malignancies, Changsha, Hunan, China.
⁴ Department of Outpatient, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
⁵ Hunan Key Laboratory of Tumor Models and Individualized Medicine, Changsha, Hunan, China.

PMID: 38616623
DOI: 10.1111/bjh.19429

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Dendritic Cells* / metabolism
Dendritic Cells* / pathology
Female
Gene Rearrangement
Hematologic Neoplasms / genetics
Hematologic Neoplasms / pathology
Hematopoietic Stem Cells / metabolism
Hematopoietic Stem Cells / pathology
Humans
Ikaros Transcription Factor* / genetics
Male
Middle Aged

Substances

Ikaros Transcription Factor
IKZF1 protein, human

Publication types

MeSH terms

Substances

Grants and funding