Nanopore Detection of METTL3-Dependent m6A-Modified mRNA Reveals a New Mechanism Regulating Cardiomyocyte Mitochondrial Metabolism

Affiliations

• ¹ Departments of Physiology and Cell Biology (C.P.R., K.K.B., F.A.), The Ohio State University, Columbus.
• ² Biomedical Engineering (C.P.R.), The Ohio State University, Columbus.
• ³ Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus (C.P.R., K.K.B., F.A.).
• ⁴ Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (C.P.R., F.A.).
• ⁵ Section of Bioinformatics and Systems Cardiology, Klaus Tschira Institute for Integrative Computational Cardiology (I.S.N.-d.V., C.D.), University Hospital Heidelberg, Germany.
• ⁶ Department of Internal Medicine III (Cardiology, Angiology, and Pneumology; I.S.N.-d.V., C.D.), University Hospital Heidelberg, Germany.
• ⁷ German Centre for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany (I.S.N.-d.V., C.D.).
• ⁸ The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, OH (C.A.M.).
• ⁹ Department of Pediatrics, University of Cincinnati College of Medicine, OH (C.A.M.).