Gold-Catalyzed Reactions of Enynals with Alkenes for Synthesis Binaphthyl Derivatives

J Org Chem. 2024 May 3;89(9):6074-6084. doi: 10.1021/acs.joc.4c00036. Epub 2024 Apr 16.

Abstract

A PPh3Au[B(C6F5)4]-catalyzed reaction of enynals and alkenes for the construction of binaphthyl derivatives was described. This transformation was achieved through o-Quinodimethane (o-QDM) intermediate's extended conjugated addition process. The reaction has the advantages of wide substrate scopes, mild reaction conditions, high efficiency, and good scalability.