Abstract
A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chagas Disease / drug therapy
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El Salvador
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Lignans* / chemistry
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Lignans* / isolation & purification
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Lignans* / pharmacology
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Molecular Structure
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Nitroimidazoles / chemistry
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Nitroimidazoles / pharmacology
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Peperomia* / chemistry
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Trypanocidal Agents* / chemistry
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Trypanocidal Agents* / isolation & purification
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Trypanocidal Agents* / pharmacology
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Trypanosoma cruzi* / drug effects
Substances
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Lignans
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Trypanocidal Agents
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benzonidazole
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Nitroimidazoles