Denosumab-induced bone changes in a child: a case report

Caroline Rutten; Claudia Martinez-Rios; Alan Daneman

doi:10.1007/s00247-024-05895-8

Denosumab-induced bone changes in a child: a case report

Pediatr Radiol. 2024 Jun;54(7):1224-1226. doi: 10.1007/s00247-024-05895-8. Epub 2024 Apr 20.

Authors

Caroline Rutten¹, Claudia Martinez-Rios¹, Alan Daneman²

Affiliations

¹ Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
² Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada. [email protected].

PMID: 38642126
DOI: 10.1007/s00247-024-05895-8

Abstract

We present the case of a 9-year-old girl who developed striking bone changes following two years of denosumab therapy for giant cell lesions of the jaw.

Keywords: Child; Denosumab; Giant cell tumor; Osseous sclerosis; RANKL; Radiography.

Publication types

Case Reports

MeSH terms

Bone Density Conservation Agents* / adverse effects
Child
Denosumab* / adverse effects
Female
Humans

Substances

Denosumab
Bone Density Conservation Agents