Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection-a Multicenter Prospective Cohort Analysis

Pranay Sinha; Komala Ezhumalai; Xinyi Du; Chinnaiyan Ponnuraja; Madolyn Rose Dauphinais; Nikhil Gupte; Sonali Sarkar; Amita Gupta; Sanjay Gaikwad; Balamugesh Thangakunam; Mandar Paradkar; Devasahayam J Christopher; Vidya Mave; Vijay Viswanathan; Jerrold J Ellner; Hardy Kornfeld; C R Horsburgh Jr; Chandrasekaran Padmapriyadarsini; Akshay Gupte

doi:10.1093/cid/ciae149

Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection-a Multicenter Prospective Cohort Analysis

Clin Infect Dis. 2024 Jul 19;79(1):233-236. doi: 10.1093/cid/ciae149.

Authors

Pranay Sinha^{1

2}, Komala Ezhumalai³, Xinyi Du², Chinnaiyan Ponnuraja⁴, Madolyn Rose Dauphinais², Nikhil Gupte^{5

6}, Sonali Sarkar³, Amita Gupta⁷, Sanjay Gaikwad⁸, Balamugesh Thangakunam⁹, Mandar Paradkar^{5

6}, Devasahayam J Christopher⁹, Vidya Mave^{5

6

7}, Vijay Viswanathan¹⁰, Jerrold J Ellner¹¹, Hardy Kornfeld¹², C R Horsburgh Jr^{2

13

14}, Chandrasekaran Padmapriyadarsini⁴, Akshay Gupte¹⁴

Affiliations

¹ Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA.
² Section of Infectious Diseases, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
³ Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
⁴ Indian Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
⁵ Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals-Johns Hopkins University Clinical Research Site, Pune, Maharashtra, India.
⁶ Center for Infectious Diseases in India, Johns Hopkins India, Pune, Maharashtra, India.
⁷ Division of Infectious Diseases, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
⁸ Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, BJMC Clinical Research Site, Pune, Maharashtra, India.
⁹ Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
¹⁰ Prof. M. Viswanathan Diabetes Research Centre, Chennai, Tamil Nadu, India.
¹¹ Center for Emerging Pathogens, Department of Medicine, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
¹² Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
¹³ Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
¹⁴ Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.

PMID: 38652286
PMCID: PMC11259213 (available on 2025-04-23)
DOI: 10.1093/cid/ciae149

Abstract

Undernutrition is the leading risk factor for tuberculosis (TB) globally and in India. This multicenter prospective cohort analysis from India suggests that undernutrition is associated with increased risk of TB disease but not TB infection among household contacts of persons with TB.

Keywords: India; infection; malnutrition; tuberculosis; undernutrition.

© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].

Publication types

Multicenter Study

MeSH terms

Adolescent
Adult
Aged
Child
Child, Preschool
Cohort Studies
Family Characteristics*
Female
Humans
India / epidemiology
Infant
Male
Malnutrition* / complications
Malnutrition* / epidemiology
Middle Aged
Prospective Studies
Risk Factors
Tuberculosis* / epidemiology
Tuberculosis* / transmission
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding