Abstract
In this brief review, we have addressed the roles of the monocyte-macrophage in atherogenesis, with emphasis on the recruitment to the arterial wall. We have presented summary data on the SMC-derived chemoattractant protein and also on the temporal evolution of monocyte-derived macrophages into cholesteryl ester-rich foam cells. The concept of atheroma as an inflammatory process has also been discussed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arteriosclerosis / pathology*
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Arteriosclerosis / physiopathology
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Chemotactic Factors / physiology
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Disease Models, Animal
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Endothelium / pathology
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Foam Cells / pathology
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Foam Cells / physiology
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In Vitro Techniques
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Inflammation / pathology*
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Inflammation / physiopathology
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Macrophages / pathology*
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Macrophages / physiology
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Monocytes / pathology*
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Monocytes / physiology
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Papio
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Phagocytosis
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Rabbits