Physiologically Based Pharmacokinetic Modeling in Pregnancy, during Lactation and in Neonates: Achievements, Challenges and Future Directions

Pharmaceutics. 2024 Apr 5;16(4):500. doi: 10.3390/pharmaceutics16040500.

Karel Allegaert^{1

2

3}, Sara K Quinney⁴, André Dallmann⁵

¹ Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
² Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
³ Department of Hospital Pharmacy, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
⁴ Department of OB/GYN, Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁵ Bayer HealthCare SAS, Loos, France, on Behalf of Bayer AG, Pharmacometrics/Modeling and Simulation, Systems Pharmacology & Medicine-PBPK, 51368 Leverkusen, Germany.

Abstract

Obstetric subjects represent a special population in pharmacology [...].