Efficacy and Safety of a Tetravalent Dengue Vaccine (TAK-003) in Children With Prior Japanese Encephalitis or Yellow Fever Vaccination

J Infect Dis. 2024 Dec 16;230(6):e1214-e1225. doi: 10.1093/infdis/jiae222.

Abstract

Background: We explored the impact of prior yellow fever (YF) or Japanese encephalitis (JE) vaccination on the efficacy of Takeda's dengue vaccine candidate, TAK-003.

Methods: Children 4-16 years of age were randomized 2:1 to receive TAK-003 or placebo and were under active febrile surveillance. Symptomatic dengue was confirmed by serotype-specific reverse-transcription polymerase chain reaction. YF and JE vaccination history was recorded.

Results: Of the 20 071 children who received TAK-003 or placebo, 21.1% had a YF and 23.9% had a JE vaccination history at randomization. Fifty-seven months after vaccination, vaccine efficacy (95% confidence interval) was 55.7% (39.7%-67.5%) in those with YF vaccination, 77.8% (70.8%-83.1%) for JE vaccination, and 53.5% (45.4%-60.4%) for no prior YF/JE vaccination. Regional differences in serotype distribution confound these results. The apparent higher vaccine efficacy in the JE vaccination subgroup could be largely explained by serotype-specific efficacy of TAK-003. Within 28 days of any vaccination, the proportions of participants with serious adverse events in the YF/JE prior vaccination population were comparable between the TAK-003 and placebo groups.

Conclusions: The available data do not suggest a clinically relevant impact of prior JE or YF vaccination on TAK-003 performance. Overall, TAK-003 was well-tolerated and efficacious in different epidemiological settings. Clinical Trials Registration. NCT02747927.

Keywords: Japanese encephalitis; TAK-003 effectiveness; dengue; vaccination; yellow fever.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Dengue Vaccines* / administration & dosage
  • Dengue Vaccines* / adverse effects
  • Dengue Vaccines* / immunology
  • Dengue Virus / immunology
  • Dengue* / prevention & control
  • Encephalitis, Japanese* / prevention & control
  • Female
  • Humans
  • Japanese Encephalitis Vaccines* / administration & dosage
  • Japanese Encephalitis Vaccines* / adverse effects
  • Japanese Encephalitis Vaccines* / immunology
  • Male
  • Vaccination
  • Vaccine Efficacy
  • Yellow Fever / immunology
  • Yellow Fever / prevention & control
  • Yellow Fever Vaccine* / administration & dosage
  • Yellow Fever Vaccine* / adverse effects
  • Yellow Fever Vaccine* / immunology

Substances

  • Dengue Vaccines
  • Yellow Fever Vaccine
  • Japanese Encephalitis Vaccines

Associated data

  • ClinicalTrials.gov/NCT02747927

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