Abstract
The concentrations of dichlorprop and its leucine conjugate in serum and bile of rats have been determined at different periods after a single oral dosage of these compounds (30 or 300 mg/kg body weight). From the results it can be concluded that dichlorprop is excreted by active renal mechanisms resembling that described for 2,4,5-T. It is suggested that the leucinate is excreted more by the biliary route. Investigations of the liver demonstrate that both compounds are able to induce mixed function oxidases.
MeSH terms
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2,4-Dichlorophenoxyacetic Acid / analogs & derivatives*
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2,4-Dichlorophenoxyacetic Acid / metabolism
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2,4-Dichlorophenoxyacetic Acid / pharmacology
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2,4-Dichlorophenoxyacetic Acid / toxicity
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Animals
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Bile / analysis
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Enzyme Induction / drug effects
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Kidney / metabolism
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Kinetics
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Leucine / metabolism
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Leucine / pharmacology
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Liver / metabolism
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Liver Function Tests
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Male
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Microsomes, Liver / drug effects
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Microsomes, Liver / enzymology
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Mixed Function Oxygenases / metabolism
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Rats
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Rats, Inbred Strains
Substances
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dichlorprop-leucine conjugate
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2,4-Dichlorophenoxyacetic Acid
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Mixed Function Oxygenases
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Leucine
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dichlorprop