Water-Mediated On-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions

Adv Healthc Mater. 2024 Jul;13(19):e2304616. doi: 10.1002/adhm.202304616. Epub 2024 May 20.

Abstract

Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.

Keywords: hydroxyapatite; internal organ retractor; pore structure; soft‐tissue adhesion; solid‐state adhesive.

MeSH terms

  • Adhesives / chemistry
  • Animals
  • Biocompatible Materials / chemistry
  • Durapatite* / chemistry
  • Liver
  • Porosity
  • Swine
  • Tissue Adhesives / chemistry
  • Tissue Adhesives / pharmacology
  • Water* / chemistry

Substances

  • Durapatite
  • Water
  • Adhesives
  • Tissue Adhesives
  • Biocompatible Materials